Patel AB, Verma A. COVID-19 and angiotensin-converting enzyme inhibitors and angiotensin receptor blockers: what is the evidence? Route; Indication; Related AE, if any; Author: Sector Pharma Created Date: 02/26/2019 10:21:00 Title: CON MEDS LAF 2203 In each study, the randomized patient population was divided into 3 subgroups based on the use of concomitant medications at study entry: a dopaminergic agonist group, a MAO-B inhibitor group (rasagiline and selegiline), and an amantadine group. American College of Cardiology. Fedson DS, Opal SM, Rordam OM. See Corticosteroids for a detailed discussion of these recommendations. Importing Instruments. Below is a list of common medications used to treat or reduce the symptoms of concomitant hypertension and osteoarthritis. HFSA/ACC/AHA statement addresses concerns re: using RAAS antagonists in COVID-19. MassHealth Drug List. Examples of concomitant in a sentence, how to use it. Select the iCRF from the drop-down list to display this report. The treatment of these other diseases has an effect on blood sugar levels, so the patient's usual diabetes treatment may have to be changed. Liggins GC, Howie RN. Stockman LJ, Bellamy R, Garner P. SARS: systematic review of treatment effects. To import this instrument please follow the instructions here. Record all concomitant medications, including therapies given to treat adverse events. https://treatmentwithcbd.com/15-medications-cbd-drug-interactions This information may be collected as a history item as well as during the study. HMG-CoA reductase inhibitors, or statins, affect ACE2 as part of their function in reducing endothelial dysfunction. Hiding in plain sight: an approach to treating patients with severe COVID-19 infection. 2020. Concomitant Opioid Benzodiazepine Initiative See Table 69 Please see the links below for a description of the Concomitant Opioid Benzodiazepine Initiative (COBI), including a medication list and frequently asked questions. Effect of dexamethasone in hospitalized patients with COVID-19: preliminary report. Horby P, Lim WS, Emberson J, et al. This is often the case in medicine. Concomitant medications were always important for the inclusion and exclusion criteria used to allow patients to take part in trials. It has been proposed that NSAIDs such as ibuprofen can increase the expression of ACE21 and inhibit antibody production.13 Shortly after these reports, the Food and Drug Administration stated that there is no evidence linking the use of NSAIDs with worsening of COVID-19 and advised patients to use NSAIDs as directed.14, Statement on Casirivimab Plus Imdevimab EUA, Chloroquine or Hydroxychloroquine With or Without Azithromycin, Clinical Data: Chloroquine or Hydroxychloroquine, Lopinavir/Ritonavir and Other HIV Protease Inhibitors, Table 2 Characteristics of Antiviral Agents, Table 3a Immune-Based Therapy Clinical Data, Table 3b Characteristics of Immune-Based Therapy, https://www.ncbi.nlm.nih.gov/pubmed/32171062, https://www.ncbi.nlm.nih.gov/pubmed/32208485, https://www.acc.org/latest-in-cardiology/articles/2020/03/17/08/59/hfsa-acc-aha-statement-addresses-concerns-re-using-raas-antagonists-in-covid-19, https://www.ncbi.nlm.nih.gov/pubmed/32362390, https://www.ncbi.nlm.nih.gov/pubmed/29161116, https://www.ncbi.nlm.nih.gov/pubmed/16968120, https://www.ncbi.nlm.nih.gov/pubmed/26950335, https://www.medrxiv.org/content/10.1101/2020.06.22.20137273v1, https://www.ncbi.nlm.nih.gov/pubmed/32232480, https://www.ncbi.nlm.nih.gov/pubmed/4561295, https://www.ncbi.nlm.nih.gov/pubmed/26842679, https://www.ncbi.nlm.nih.gov/pubmed/32198163, https://www.ncbi.nlm.nih.gov/pubmed/19345936, https://www.fda.gov/drugs/drug-safety-and-availability/fda-advises-patients-use-non-steroidal-anti-inflammatory-drugs-nsaids-covid-19, Persons with COVID-19 who are prescribed ACE inhibitors or ARBs for cardiovascular disease (or other indications) should continue these medications, The COVID-19 Treatment Guidelines Panel (the Panel), On the basis of the preliminary report from the Randomised Evaluation of COVID-19 Therapy (RECOVERY) trial, the Panel recommends using, If dexamethasone is not available, the Panel recommends using alternative glucocorticoids such as, Oral corticosteroid therapy that was used prior to COVID-19 diagnosis for another underlying condition (e.g., primary or secondary adrenal insufficiency, rheumatological diseases) should not be discontinued, Inhaled corticosteroids that are used daily for patients with asthma and chronic obstructive pulmonary disease for control of airway inflammation should not be discontinued in patients with COVID-19, Given the potential benefit of decrease in maternal mortality and the low risk of fetal adverse effects for this short course of therapy, the Panel recommends using, Persons with COVID-19 who are prescribed statin therapy for the treatment or prevention of cardiovascular disease should continue these medications, Persons with COVID-19 who are taking NSAIDs for a comorbid condition should continue therapy as previously directed by their physician, The Panel recommends that there be no difference in the use of antipyretic strategies (e.g., with acetaminophen or NSAIDs) between patients with or without COVID-19, Persons with COVID-19 who are prescribed angiotensin-converting enzyme (ACE) inhibitors or angiotensin receptor blockers (ARBs) for cardiovascular disease (or other indications) should continue these medications, Persons with COVID-19 who are taking nonsteroidal anti-inflammatory drugs (NSAIDs) for a comorbid condition should continue therapy as previously directed by their physician, The Panel recommends that there be no difference in the use of antipyretic strategirs (e.g., with acetaminophen or NSAIDs) between patients with or without COVID-19. 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